Concepedia

Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults

Nitin Jain, Kathryn G. Roberts, Elias Jabbour, Keyur P. Patel, Agda Karina Eterovic, Ken Chen, Patrick A. Zweidler‐McKay, Xinyan Lu, Gloria L. Fawcett, Sa A. Wang,

Blood · 2016 · 386 citations · 36 references

DOIFull text

Open access

Concepts

Abstract

Key Points Approximately 20% to 25% of adults with B-ALL have Ph-like ALL with increased frequency of Ph-like ALL in adults with Hispanic ethnicity. Adult patients with CRLF2+ ALL have poor long-term outcomes; novel strategies are needed to improve the outcomes.

References

36

Deletion of <i>IKZF1</i> and Prognosis in Acute Lymphoblastic Leukemia

Charles G. Mullighan, Xiaoping Su, Jinghui Zhang et al. · New England Journal of Medicine · 2009 · 1.4K citations · Full text

, , +15

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

Kathryn G. Roberts, Yongjin Li, Debbie Payne-Turner et al. · New England Journal of Medicine · 2014 · 1.4K citations · Full text

, , +17

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

Charles G. Mullighan, Christopher B. Miller, Ina Radtke et al. · Nature · 2008 · 1.1K citations

, , +9

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

Monique L. den Boer, Marjon van Slegtenhorst, Renée X. de Menezes et al. · The Lancet Oncology · 2009 · 925 citations · Full text

, , +16

In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)

Anthony H. Goldstone, Susan Richards, Hillard M. Lazarus et al. · Blood · 2007 · 782 citations · Full text

, , +16