Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure

Abstract

Our findings identify NDPK-C as an essential requirement for both the interaction between NDPK isoforms and between NDPK isoforms and G proteins. NDPK-C is a novel critical regulator of β-adrenoceptor/cAMP signaling and cardiac contractility. By switching from Gα_s to Gα_i2 activation, NDPK-C may contribute to lower cAMP levels and the related contractile dysfunction in HF.