Synthesis of an Enantipure Tetrazole-Based Homochiral Cu^I,II-MOF for Enantioselective Separation

Abstract

An enantipure (1 S )-1-(5-tetrazolyl)ethylamine (5-eatz) ligand was first employed to construct a homochiral porous metal–organic framework, {[Cu I 2 Cu II (5-eatz) 2 (CN – )(H 2 O)] + [NO 3 – ]}·[DMF] ( 1 ), with unusual ligand-unsupported Cu···Cu interactions. Such a compound shows high stability in water and common organic solvents. Remarkably, it has high enantioselectivity toward ( R, S )-1-phenylethanol and ( R, S )-1-phenylpropanol with enantiomeric excess values of up to 42% and 48%, respectively.