Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis

Abstract

MRS [ myo-inositol] and PET [¹¹C]PBR28 measure independent inflammatory processes which may be more commonly found together with more severe inflammatory disease. Microglial activation measured by [¹¹C]PBR28 uptake was associated with loss of neuronal integrity and grey matter atrophy.