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Placental Transfer and Biological Half-life of Radioactive Vit. B12 in the Dog.
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1959
Year
FertilityGynecologyEmbryologyPlacental TransferSummaryplacental TransferPublic HealthPlacental DevelopmentAnimal PhysiologyRadioactive VitMaternal-fetal MedicinePlacental FunctionResidual Radioactive VitaminTheriogenologyDevelopmental BiologyBiological Half-lifeAnimal SciencePhysiologyVeterinary ScienceMedicine
SummaryPlacental transfer of radioactive Vit. B12 in the dog following pregestational administration, was found in the entire litter to be 20% of the residual radioactive vitamin in the bitch at time of delivery. Because the proportional distribution of radioactive B12 among major organs of the mother and pups was found to be similar, it was possible to calculate placental transfer from this characteristic as well as by postpartum "calibration" of the hepatic radioactivity in pups. Biological half-life of the radioactive Vit. B12 averaged 2 months in pups and bitch during postpartum period. A new explanation is suggested for the low maternal and high fetal plasma levels of Vit. B12.