Thyroid transcription factor-1 distinguishes subependymal giant cell astrocytoma from its mimics and supports its cell origin from the progenitor cells in the medial ganglionic eminence

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

Shioko Kimura, Yasumasa Hara, Thierry Pineau et al. · Genes & Development · 1996 · 1.2K citations · Full text

Life Sciences, Genetics, Molecular Genetics +15

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

Genevieve Schindler, David Capper, Jochen Meyer et al. · Acta Neuropathologica · 2011 · 1K citations

Medicine, Genetics, Oncology +14

The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain

Domenico Lazzaro, Melanie Price, Mario De Felice et al. · Development · 1991 · 901 citations

Life Sciences, Developmental Biology, Molecular Biology +13

Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial

David Neal Franz, Steven Sparagana, E. Martina Bebin et al. · The Lancet · 2012 · 784 citations

Medicine, Neurology, Oncology +10

Thyroid nuclear factor 1 (TTF‐1) contains a homeodomain and displays a novel DNA binding specificity.

Stefania Guazzi, Melanie Price, Mario De Felice et al. · The EMBO Journal · 1990 · 541 citations · Full text

Life Sciences, Genetics, Molecular Biology +8