Copper‐Catalyzed Bromination of C(sp³)−H Bonds Distal to Functional Groups

Abstract

Selective bromination of γ-methylene C(sp³ )-H bonds of aliphatic amides and δ-methylene C(sp³ )-H bonds of nosyl-protected alkyl amines are developed using NBS as the brominating reagent and catalytic amount of Cu^II /phenanthroline complexes as the catalyst. Aryl and benzylic C-H bonds at other locations remain intact during this directed radical abstraction reaction.