Whole-genome metabolic model of Trichoderma reesei built by comparative reconstruction

Abstract

The improvements presented in this work on the CoReCo pipeline for metabolic model reconstruction resulted in higher-quality metabolic models compared with previous versions. A metabolic model of <i>T. reesei</i> has been created and is publicly available in the BIOMODELS database. The model contains a biomass equation, reaction boundaries and uptake/export reactions which make it ready for simulation. To validate the model, we dem1onstrate that the model is able to predict biomass production accurately and no stoichiometrically infeasible yields are detected. The new <i>T. reesei</i> model is ready to be used for simulations of protein production processes.