Publication | Closed Access
Perfluoroalkyl Analogues of Diethylaminosulfur Trifluoride: Reagents for Perfluoroalkylthiolation of Active Methylene Compounds under Mild Conditions
37
Citations
32
References
2016
Year
Trifluoromethyl diethylaminosulfur difluoride (CF<sub>3</sub>-DAST) was found to be an efficient reagent for the trifluoromethylthiolation of α-methylene-β-keto esters providing α-trifluoromethylthio-β-keto esters in good to high yields. α-Methylene-β-keto sulfones were also accepted as substrates by CF<sub>3</sub>-DAST to furnish the corresponding α-trifluoromethylthio compounds. This strategy can be extended to perfluoroalkylthiolation reactions using perfluoroethyl-DAST (C<sub>2</sub>F<sub>5</sub>-DAST) and perfluoropropyl-DAST (C<sub>3</sub>F<sub>7</sub>-DAST).
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