Another Example of Organo‐Click Reactions: TEMPO‐Promoted Oxidative Azide–Olefin Cycloaddition for the Synthesis of 1,2,3‐Triazoles in Water

Abstract

The water‐mediated, metal‐free, 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) promoted oxidative [3+2] cycloaddition of organic azides with electron‐deficient terminal and internal olefins was explored. A library of 1,4‐disubstituted and 1,4,5‐trisubstituted‐1,2,3‐triazoles were synthesized in moderate to excellent yields. This method was also found to be compatible not only with open‐chain olefins but also with cyclic olefins.