Concepedia

Expanding the reaction space of aldolases using hydroxypyruvate as a nucleophilic substrate

Véronique de Berardinis, Christine Guérard‐Hélaine, Ekaterina Darii, Karine Bastard, Virgil Hélaine, Aline Mariage, Jean‐Louis Petit, Nicolas Poupard, Israel Sánchez‐Moreno, Mark Stam,

Green Chemistry · 2016 · 34 citations · 45 references

DOI

Concepts

Abstract

Hydroxypyruvate was shown to be a nucleophile for class II pyruvate aldolases isolated from biodiversity, allowing unprecedented stereoselective cross-aldol reactions.

References

45

Rational assignment of key motifs for function guides in silico enzyme identification

Matthias Höhne, Sebastian Schätzle, Helge Jochens et al. · Nature Chemical Biology · 2010 · 369 citations

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Biocatalytic retrosynthesis

Nicholas J. Turner, Elaine O’Reilly · Nature Chemical Biology · 2013 · 341 citations

Fructose-6-phosphate Aldolase Is a Novel Class I Aldolase from Escherichia coli and Is Related to a Novel Group of Bacterial Transaldolases

Melanie Schürmann, Georg A. Sprenger · Journal of Biological Chemistry · 2001 · 206 citations · Full text

, , +5

Enantioselective organocatalytic aldol reaction using small organic molecules

Vishnumaya Bisai, Alakesh Bisai, Vinod K. Singh · Tetrahedron · 2012 · 165 citations

, , +9

Metabolic Pathway Promiscuity in the Archaeon Sulfolobus solfataricus Revealed by Studies on Glucose Dehydrogenase and 2-Keto-3-deoxygluconate Aldolase

Henry J. Lamble, Narinder I. Heyer, Steven D. Bull et al. · Journal of Biological Chemistry · 2003 · 149 citations · Full text

, , +15