Neuroendocrine tumors of colon and rectum: validation of clinical and prognostic values of the World Health Organization 2010 grading classifications and European Neuroendocrine Tumor Society staging systems

Abstract

// Chaoyong Shen 1, * , Yuan Yin 1, * , Huijiao Chen 2 , Sumin Tang 1 , Xiaonan Yin 1 , Zongguang Zhou 1, 3 , Bo Zhang 1 , Zhixin Chen 1 1 Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China 2 Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China 3 Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China * These authors have contributed equally to this work Correspondence to: Zongguang Zhou, email: zhou767@163.com Bo Zhang, email: hxwcwk@126.com Keywords: neuroendocrine tumors, colorectal, prognosis, WHO classifications, ENETS TNM systems Received: August 23, 2016      Accepted: November 08, 2016      Published: November 26, 2016 ABSTRACT Background/Aims: This study evaluated and compared the clinical and prognostic values of the grading criteria used by the World Health Organization (WHO) and the European Neuroendocrine Tumors Society (ENETS). Moreover, this work assessed the current best prognostic model for colorectal neuroendocrine tumors (CRNETs). Results: The 2010 WHO classifications and the ENETS systems can both stratify the patients into prognostic groups, although the 2010 WHO criteria is more applicable to CRNET patients. Along with tumor location, the 2010 WHO criteria are important independent prognostic parameters for CRNETs in both univariate and multivariate analyses through Cox regression ( P <0.05). Methods: Data from 192 consecutive patients histopathologically diagnosed with CRNETs and had undergone surgical resection from January 2009 to May 2016 in a single center were retrospectively analyzed. Conclusions: Findings suggest that the WHO classifications are superior over the ENETS classification system in predicting the prognosis of CRNETs. Additionally, the WHO classifications can be widely used in clinical practice.