Retinoic acid signaling regulates <i>Krt5</i> and <i>Krt14</i> independently of stem cell markers in submandibular salivary gland epithelium

Abstract

RA regulates Krt5 and Krt14 expression independently of stem cell character in developing salivary epithelium. RA, or chemical inhibitors of RA signaling, could potentially be used for modulating growth and differentiation of epithelial stem cells for the purpose of re-populating damaged glands or generating bioengineered organs. Developmental Dynamics 246:135-147, 2017. © 2016 Wiley Periodicals, Inc.