Thermal analysis of interactions between an oxime and excipients in some binary mixtures by differential scanning calorimetry and thermagravimetric analysis

Abstract

Thermal analysis methods are widely used in all fields of pharmaceutical sciences but especially in preformulation studies. These techniques are unique for the characterization of single compounds and mixtures. The information correlated with the thermodynamic phase diagrams is extremely helpful for rational preformulation studies and development of novel drug delivery systems. Excipients found compatible can be chosed for formulation developement. Different excipients were checked and evaluated with obidoxime chloride by using thermal analytical techniques. All the binary mixtures represent the characteristic Obidoxime chloride peak. All the excipients found compatible compatible with Obidoxime chloride.