Journal of the American Chemical Society · 2016 · 121 citations · 37 references
Natural SciencesChemical EngineeringChemistryCatalysisInorganic ChemistryOrganic ChemistryBeta-hydride EliminationCatalyst DesignCatalyst PreparationCatalytic MaterialsCatalytic Reaction EngineeringOrganic SynthesisCatalytic FunctionalizationChemo-selectivityCis-β-hydride EliminationHydride FormationHydride Transfer ProcessesMetal Alkyl Hydride IntermediatesPrevention Of Beta-hydride EliminationTrans-β-hydride Elimination
A catalytic hydroamidation of alkynes with isocyanates using alkyl bromides as hydride sources has been developed. The method turns parasitic β-hydride elimination into a strategic advantage, rapidly affording acrylamides with excellent chemo- and regioselectivity.
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