Positive versus negative effects of VEGF₁₆₅ on Ca²⁺ signaling and NO production in human endothelial cells

Abstract

In this manuscript, we show that VEGF levels associated with preeclampsia are a net negative contributor to potential vasodilator production in both a human ex vivo and in vitro endothelial cell model. Therefore, pharmacological targeting of VEGF-stimulated signaling pathways could be a novel treatment modality for preeclampsia-related hypertension.