Activity-dependent formation and location of voltage-gated sodium channel clusters at a CNS nerve terminal during postnatal development

Abstract

Clustering of voltage-gated sodium (Na_v) channels and their distribution along the axon, specifically at the unmyelinated axon segment next to the nerve terminal, are essential for tuning propagated action potentials. Na_v channel clusters near the nerve terminal and their location as a function of neuronal position along the mediolateral axis are controlled by auditory inputs after hearing onset. Thus sound-mediated neuronal activity influences the tonotopic organization of Na_v channels at the nerve terminal in the auditory brain stem.