One Pot Single Step Synthesis and Biological Evaluation of Some Novel Bis(1,3,4-thiadiazole) Derivatives as Potential Cytotoxic Agents

Abstract

A novel series of <i>bis</i>(1,3,4-thiadiazole) derivatives were synthesized in one step methodology with good yields by condensation reaction between <i>bis</i>-hydrazonoyl chloride <b>1</b> and various reagents. The structures of the prepared compounds were confirmed by spectral data (IR, NMR, and MS), and elemental analysis. The anticancer activity against human breast carcinoma (MCF-7) cancer cell lines was evaluated in MTT assay. The results revealed that the <i>bis</i>-thiadiazole derivatives <b>5c</b>,<b>d</b>, <b>7b</b>,<b>c</b> and <b>9c</b> had higher antitumor activity than the standard drug Imatinib.