Concepedia

Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma

Marrah E. Lachowicz-Scroggins, Shaopeng Yuan, Sheena C. Kerr, Eleanor M. Dunican, Michelle Yu, Stephen D. Carrington, John V. Fahy

American Journal of Respiratory and Critical Care Medicine · 2016 · 161 citations · 9 references

DOI

Concepts

Abstract

Definition of abbreviation: n/a = not available.Asthma was diagnosed by either methacholine hyperresponsiveness or bronchodilator responsiveness.*Age, body mass index, and spirometry data are presented as mean 6 SD.† Sputum cell count data is presented as the median (range).

References

9

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

Prescott G. Woodruff, Barmak Modrek, David F. Choy et al. · American Journal of Respiratory and Critical Care Medicine · 2009 · 1.8K citations · Full text

, , +16

Muc5b is required for airway defence

Michelle G. Roy, Alessandra Livraghi-Butrico, Ashley A. Fletcher et al. · Nature · 2013 · 773 citations

, , +8

Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B

Sara Kirkham, John K. Sheehan, David Knight et al. · Biochemical Journal · 2002 · 306 citations · Full text

, , +13

The polymeric mucin Muc5ac is required for allergic airway hyperreactivity

Christopher M. Evans, Dorota S. Raclawska, Fani Ttofali et al. · Nature Communications · 2015 · 289 citations · Full text

, , +14

Oxidation increases mucin polymer cross-links to stiffen airway mucus gels

Shaopeng Yuan, Martin Hollinger, Marrah E. Lachowicz-Scroggins et al. · Science Translational Medicine · 2015 · 260 citations · Full text

, , +9