Evidence of an Epistatic Effect Between Dysbindin-1 and Neuritin-1 Genes on the Risk for Schizophrenia Spectrum Disorders

Abstract

Our results suggest that DTNBP1 and NRN1 genes show a joint effect on the risk for SSD. Although the precise mechanism underlying this effect is unclear, the fact that these genes have been involved in synaptic maturation, connectivity and glutamate signalling suggests that our findings could be of value as a link to the schizophrenia aetiology.