Highly potent extranuclear-targeted luminescent iridium(<scp>iii</scp>) antitumor agents containing benzimidazole-based ligands with a handle for functionalization

Abstract

values in the high nanomolar range in some ovarian and breast cancer cell lines (approximately 100× more cytotoxic than cisplatin (CDDP) in MDA-MB-231) and are located in the actin cortex predominantly as shown by confocal luminescence microscopy. This discovery could open the door to a new large family of drug bioconjugates with diverse and simultaneous functions.