Palladium‐Catalyzed Tandem Oxidative Arylation/Olefination of Aromatic Tethered Alkenes/Alkynes

Abstract

Abstract We describe herein a palladium‐catalyzed tandem oxidative arylation/olefination reaction of aromatic tethered alkenes/alkynes for the synthesis of dihydrobenzofurans and 2 H ‐chromene derivatives. This reaction features a 1,2‐difunctionalization of C−C π‐bond with two C−H bonds using O 2 as terminal oxidant at room temperature. The products obtained are valuable synthons and important scaffolds in biological agents and natural products.