Radical (Phenylsulfonyl)difluoromethylation of Isocyanides with PhSO₂CF₂H under Transition-Metal-Free Conditions

Abstract

An atom-economical method for radical (phenylsulfonyl)difluoromethylation of isocyanides with PhSO₂CF₂H under transition-metal-free conditions has been developed. A PhSO₂CF₂ radical is generated through the oxidation of PhSO₂CF₂^- after the deprotonation of PhSO₂CF₂H in one pot. The reaction exhibits excellent functional-group tolerance and the resulting products can be further modified with the removal of a PhSO₂ group to give other CF₂-containing compounds.