A prospective study of treatment of carbapenem-resistant Enterobacteriaceae infections and risk factors associated with outcome

Abstract

CRE infection mortality was higher among patients with pneumonia. Infections caused by colistin-resistant isolates did not increase mortality. The use of more than two drugs on combination therapy did not show a protective effect on outcome. The isolates were polyclonal, and the bla _KPC gene was the only carbapenemase found. Shock, dialysis, and age over 60 years were independent risk factors for death.