PLoS Genetics · 2016 · 145 citations · 59 references
Life SciencesPlant BiologyPlant SciencesGene ExpressionPlant Molecular BiologyPlant PhysiologyAbiotic Stress ToleranceDrought Stress PhysiologyPlant Small Rna BiologyPlant Transcriptional RegulationStress BiochemistryTranscriptomics Of Stress ResponsesAbiotic StressAbiotic Stress SignalingDrought Stress Response GenesGene Expression Regulation Under DroughtGene Expression Under Abiotic StressMicrorna-mediated Stress ToleranceStress-induced ToleranceTranscription Factors In Stress Response
The function of miR165/166 in plant growth and development has been extensively studied, however, its roles in abiotic stress responses remain largely unknown. Here, we report that reduction in the expression of miR165/166 conferred a drought and cold resistance phenotype and hypersensitivity to ABA during seed germination and post-germination seedling development. We further show that the ABA hypersensitive phenotype is associated with a changed transcript abundance of ABA-responsive genes and a higher expression level of ABI4, which can be directly regulated by a miR165/166 target. Additionally, we found that reduction in miR165/166 expression leads to elevated ABA levels, which occurs at least partially through the increased expression of BG1, a gene that is directly regulated by a miR165/166 target. Taken together, our results uncover a novel role for miR165/166 in the regulation of ABA and abiotic stress responses and control of ABA homeostasis.
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