Stromal Cell-Derived Factor-1 Retention and Cardioprotection for Ischemic Myocardium

Abstract

These results show that a single dose of protease-resistant SSDF-1(S4V) after myocardial infarction leads to dramatic improvement in angiogenesis and ventricular function even 3 hours after the onset of ischemia, revealing a simple, clinically feasible approach to prevention of heart failure.