Clinical relevance of RORγ positive and negative subsets of CD161⁺CD4⁺T cells in primary Sjögren’s syndrome

Abstract

In addition to pointing to CD161 as a marker of a pathogenic subset of CD4⁺ T cells in pSS patients, our data indicate that even though the RORγ⁺ (Th17) CD161⁺ subset might contribute to humoral manifestations of the disease, the RORγ^- (non-Th17) CD161⁺ subset is the one associated with disease activity in pSS patients.