Blood · 2016 · 41 citations · 46 references
Life SciencesCell BiologyMolecular BiologyCell SignalingMolecular OncologySignal TransductionCancer Cell SignalingCancer Stem Cell BiologyCancer Stem Cell MaintenanceCancer Stem CellsDna Damage-induced ApoptosisSignal Transduction In CancerAcute LeukemiasAcute Myeloid Leukemia BiologyAcute Myeloid Leukemia ProgressionAcute Myeloid Leukemia TherapyBone Marrow Erythroid ProgenitorsP53 MutationP53-dependent Apoptotic SignalingP53-mediated Signaling
synergizes with enhanced oncogenic Nras signaling to transform MEPs and drive AML development. This model may serve as a platform to test candidate therapeutics in this aggressive subset of AML.
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Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
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