Palladium(II) Acetate‐Catalyzed Dual C–H Functionalization and C–C Bond Formation: A Domino Reaction for the Synthesis of Functionalized (<i>E</i>)‐Bisindole‐2‐ones from Diarylbut‐2‐ynediamides

Abstract

Abstract A domino reaction of palladium(II)‐catalyzed dual C–H functionalization with subsequent intramolecular annulation is presented. This method provides a convenient synthesis of a range of symmetrical and unsymmetrical biologically important ( E )‐bisindole‐2‐ones under extremely mild reaction conditions – room temperature, green oxidant and no additive. The reaction mechanism is elucidated in light of the yield values as well as additional control experiment results. magnified image