A New Antifungal Isocoumarin from The Endophytic Fungus <i>Trichoderma</i> Sp. 09 of <i>Myoporum bontioides</i> A. Gray.

Abstract

A new isocoumarin named dichlorodiaportinolide, along with dichlorodiaportin, diaportinol, and diaportin were isolated from the endophytic fungus <i>Trichoderma</i> sp. 09 of the root of <i>Myoporum bontioides</i>.Dichlorodiaportinolide and dichlorodiaportin showed weak to high antifungal activities against <i>musae and R. solani</i> (MIC values from 6.25 to 150 μg/mL).Dichlorodiaportinolide and dichlorodiaportin were inactive to <i>P. italic</i> and <i>F. graminearum</i> (MIC values > 200 μg/mL). <b>Abbreviations used:</b> IR: Infrared Radiation, HR-ESI-MS: High resolution electrospray ionization mass spectroscopy, LCMS-IT-TOF: Liquid chromatography mass spectroscopy-Ion trap-Time-of-flight, UV: Ultraviolet-visible, HMBC: Heteronuclear multiple bond correlation, NOE: Nuclear Overhauser effect.