Clonidine preconditioning alleviated focal cerebral ischemic insult in rats via up-regulating p-NMDAR1 and down-regulating NMDAR2A / p-NMDAR2B

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.5K citations · Full text

Medicine, Neuroscience, Surgery +17

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

Weihong Tu, Xin Xu, Lisheng Peng et al. · Cell · 2010 · 491 citations · Full text

Medicine, Neurobiology, Neuroscience +12

Dexmedetomidine Improves Neurologic Outcome from Incomplete Ischemia in the Rat Reversal by the α2-Adrenergic Antagonist Atipamezole

William E. Hoffman, E. Kochs, Christian Werner et al. · Anesthesiology · 1991 · 284 citations · Full text

Medicine, Anesthesiology, Pharmacology +16

Neuroprotection by the α2-Adrenoreceptor Agonist Dexmedetomidine in a Focal Model of Cerebral Ischemia

Carolina M. Maier, Gary K. Steinberg, Guo Hua Sun et al. · Anesthesiology · 1993 · 236 citations · Full text

Medicine, Anesthesiology, Neurosurgery +16

A Point Mutation of the α ₂ -Adrenoceptor that Blocks Coupling to Potassium but not Calcium Currents

Annmarie Surprenant, Debra A. Horstman, Hamid I. Akbarali et al. · Science · 1992 · 164 citations

Life Sciences, Biochemistry, Pharmacology +15