Altered DNA Methylation of Long Noncoding RNA <i>H19</i> in Calcific Aortic Valve Disease Promotes Mineralization by Silencing <i>NOTCH1</i>

Abstract

These findings indicate that a dysregulation of DNA methylation in the promoter of H19 during calcific aortic valve disease is associated with a higher expression of this lncRNA, which promotes an osteogenic program by interfering with the expression of NOTCH1.