An Antibacterial Zn–MOF with Hydrazinebenzoate Linkers

Abstract

A Zn‐based metal–organic framework (MOF) with hydrazinebenzoate linkers was evaluated as antimicrobial material against the Gram‐positive bacterium Staphylococcus aureus . The material inhibits bacterial growth and metabolic activity, with a half maximal effective concentration of about 20 mg L –1 material dispersed in the culture medium. The antimicrobial effect can be attributed to the release of the 4‐hydrazinebenzoate linker, with a negligible contribution from the free metal. The material exhibits remarkable durability, and it enables the sustained release of the ligand over a period of several days.