DrugCentral: online drug compendium

TLDR

DrugCentral is an open‑access online drug compendium. DrugCentral aggregates and cross‑references drug structures, bioactivities, regulatory status, pharmacologic actions, indications, formulations, and label annotations, linking drug–target interactions to therapeutic use and enabling text‑mining of adverse events and clinical trials, and is kept current through continuous monitoring of regulatory approvals. The study reports that DrugCentral shares chemical structure overlap with five other drug resources and that its FDA‑approved drugs are represented in four distinct chemical collections.

Abstract

DrugCentral (http://drugcentral.org) is an open-access online drug compendium. DrugCentral integrates structure, bioactivity, regulatory, pharmacologic actions and indications for active pharmaceutical ingredients approved by FDA and other regulatory agencies. Monitoring of regulatory agencies for new drugs approvals ensures the resource is up-to-date. DrugCentral integrates content for active ingredients with pharmaceutical formulations, indexing drugs and drug label annotations, complementing similar resources available online. Its complementarity with other online resources is facilitated by cross referencing to external resources. At the molecular level, DrugCentral bridges drug-target interactions with pharmacological action and indications. The integration with FDA drug labels enables text mining applications for drug adverse events and clinical trial information. Chemical structure overlap between DrugCentral and five online drug resources, and the overlap between DrugCentral FDA-approved drugs and their presence in four different chemical collections, are discussed. DrugCentral can be accessed via the web application or downloaded in relational database format.