Plasma endothelin-1 and single nucleotide polymorphisms of <i>endothelin-1 and endothelin type A receptor genes</i> as risk factors for normal tension glaucoma.

Abstract

Polymorphic variants of <i>endothelin EDN</i> (K198N) and <i>endothelin receptor type A genes EDN RA</i> (C1222T, C70G, G231A) affected ET plasma concentrations. There was no association between the plasma endothelin levels and the risk factors for NTG. According to these results, plasma endothelin concentrations do not appear to be a marker for NTG.