<i>TSHR</i> Gene Polymorphisms in the Enhancer Regions Are Most Strongly Associated with the Development of Graves’ Disease, Especially Intractable Disease, and of Hashimoto's Disease

Abstract

Among the evaluated TSHR gene SNPs, the rs4411444 GG genotype and the rs4903961 C allele in the enhancer regions of the TSHR gene were most strongly associated with the development of GD, especially intractable disease, and that of HD, respectively.