Asymmetric synthesis of (S)-phenylacetylcarbinol – closing a gap in C–C bond formation

Abstract

By the combination of biocatalyst design and reaction engineering, the so far not stereoselectively accessible (<italic>S</italic>)-phenylacetylcarbinol could be enzymatically synthesized with product concentrations &gt;48 g L⁻¹ and an enantiomeric excess up to 97%.