Asymmetric Induction by a Nitrogen ¹⁴N/¹⁵N Isotopomer in Conjunction with Asymmetric Autocatalysis

Abstract

Chirality arising from isotope substitution, especially with atoms heavier than the hydrogen isotopes, is usually not considered a source of chirality in a chemical reaction. An N² ,N² ,N³ ,N³ -tetramethyl-2,3-butanediamine containing nitrogen (¹⁴ N/¹⁵ N) isotope chirality was synthesized and it was revealed that this isotopically chiral diamine compound acts as a chiral initiator for asymmetric autocatalysis.