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Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits

DOIFull Paper Access

626

Citations

15

References

2016

Year

Antonius Baartscheer, Cees A. Schumacher, Rob C. I. Wüst, Jan W.T. Fiolet, Ger J.M. Stienen, Ruben Coronel, Coert J. Zuurbier
Diabetologia

Abstract

The glucose lowering kidney-targeted agent, EMPA, demonstrates direct cardiac effects by lowering myocardial [Na<sup>+</sup>]<sub>c</sub> and [Ca<sup>2+</sup>]<sub>c</sub> and enhancing [Ca<sup>2+</sup>]<sub>m</sub>, through impairment of myocardial NHE flux, independent of SGLT2 activity.

References

YearCitations

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