Two New Atisine-Type C20-Diterpenoid Alkaloids from Aconitum leucostomum

Abstract

Two new atisine-type C20-diterpenoid alkaloids, leucostomine A (1) and leucostomine B (2) were isolated from the root of Aconitum leucostomum.Their structures were determined by spectroscopic methods including 1D-, 2D-NMR, and HR-ESI-MS.Aconitum leucostomum Worosch.(Ranunculaceae) is a perennial herb distributed in the Gansu Province and Xinjiang Uygur Autonomous Region of China.It has been used as a folk medicine for the treatment