Serological specificity of IgG and IgM antiglobulin antibodies in anti-Gm(a) antisera.

Abstract

Serological study of a chromatographed Ragg anti-Gm(a) serum has shown differences in specificity of the IgG serum agglutinators and the IgM rheumatoid factor monospecific for Gm(a). The specificity of the IgG serum agglutinators is determined by the enzymatic modification of the globulin molecules and is unrelated to the Gm type. Both serum agglutinators and anti-Gm(a) antibodies were demonstrable in a (heterologous) baboon anti-Gm(a) serum; however, both types of antibodies in this animal were IgG.