Immunomodulatory/inflammatory effects of geopropolis produced by <i>Melipona fasciculata</i> Smith in combination with doxorubicin on THP-1 cells

Abstract

GEO exerted a pro-inflammatory profile by increasing TLR-4 and CD80 expression and TNF-α production, favouring the activation of the immune/inflammatory response. GEO + DOX did not affect cell viability and presented an immunomodulatory action. Lower concentrations of DOX combined to GEO could be used in cancer patients, avoiding side effects and benefiting from the biological properties of GEO.