I₂/CHP‐Mediated Oxidative Coupling of 2‐Aminobenzamides and Isocyanides: Access to 2‐Aminoquinazolinones

Abstract

An oxidative coupling of 2‐aminobenzamides 1 and isocyanides 2 mediated by I 2 and cumyl hydroperoxide (CHP) leads to the formation of 2‐aminoquinazolinones 3 in moderate to excellent yields. This method provides an efficient approach to 2‐aminoquinazolinones with high atom economy under metal‐free conditions through two C–N bond‐formation reactions. The products can be further transformed to give benzo[4,5]imidazo[2,1‐ b ]quinazolin‐12(6 H )‐one ( 4 ).