Cyclooxygenase-2 inhibitor celecoxib attenuates joint contracture following immobilization in rat knees

Abstract

Oral administration of celecoxib partially reduced myogenic ROM restriction concomitantly with knee flexor muscle shortening following immobilization. These results imply that inflammation and nociception are involved in myogenic contracture formation independently of joint immobilization, and that CBX is effective in preventing joint contracture following immobilization in rats.