Apparent Carbon Monoxide Insertion <i>via</i> Double Isocyanide Incorporation during Palladium‐Catalyzed Construction of Indoloquinoline Ring in a Single Pot: Synthesis of New Cytotoxic Agents

Abstract

Abstract The formation of an amide bond via incorporation of two isocyanide units during a palladium‐catalyzed construction of the indoloquinoline ring afforded N ‐substituted 6 H ‐indolo[2,3‐ b ]quinoline‐11‐carboxamides as new cytotoxic agents. The solvent and base play a key role in the selective and unprecedented synthesis of this class of amides. magnified image