New Sesquiterpenoids and Anti-Platelet Aggregation Constituents from the Rhizomes of Curcuma zedoaria

Abstract

Two new sesquiterpenoids-13-hydroxycurzerenone (<b>1</b>) and 1-oxocurzerenone (<b>2</b>)-have been isolated from the rhizomes of <i>Curcuma zedoaria</i>, together with 13 known compounds (<b>3</b>-<b>15</b>). The structures of two new compounds were determined through spectroscopic and MS analyses. Among the isolated compounds, 13-hydroxycurzerenone (<b>1</b>), 1-oxocurzerenone (<b>2</b>), curzerenone (<b>3</b>), germacrone (<b>4</b>), curcolone (<b>5</b>), procurcumenol (<b>6</b>), ermanin (<b>7</b>), curcumin (<b>8</b>), and a mixture of stigmast-4-en-3,6-dione (<b>12</b>) and stigmasta-4,22-dien-3,6-dione (<b>13</b>) exhibited inhibition (with inhibition % in the range of 21.28%-67.58%) against collagen-induced platelet aggregation at 100 μM. Compounds <b>1</b>, <b>5</b>, <b>7</b>, <b>8</b>, and the mixture of <b>12</b> and <b>13</b> inhibited arachidonic acid (AA)-induced platelet aggregation at 100 μM with inhibition % in the range of 23.44%-95.36%.