Sodium Chloride Catalyzed Regioselective Trifluoromethylthiolation of Furans

Abstract

Here, we report the catalytic trifluoromethylthiolation of furans employing sodium chloride as an inexpensive, abundant and ecologically friendly catalyst. The developed method exhibits perfect regio­selectivity and a high functional group tolerance. Furthermore, the robustness of the newly developed method was determined by the additive­-based <i>Robustness Screen</i>.