High Frequency of <i>GBA</i> Gene Mutations in Dementia With Lewy Bodies Among Ashkenazi Jews

Abstract

One in 3 AJ patients diagnosed with DLB were carriers of a GBA mutation, making it the most common genetic mutation identified in association with this disease and with any dementia disorder. Mutations in the GBA gene were associated with more severe motor and cognitive dysfunction, supporting a specific contribution of the GBA gene or lysosome function to this clinical syndrome.