Evaluation of <scp>MDRD</scp>4, <scp>CKD</scp>‐<scp>EPI</scp>,<scp> BIS</scp>‐1, and modified Cockcroft–Gault equations to estimate glomerular filtration rate in the elderly renal‐transplanted recipients

Abstract

Abstract Equations to estimate glomerular filtration rate ( eGFR ) were developed in patients using the variables age, body weight, and serum creatinine, which may be different in the elderly. Elderly renal transplant patients ( EG ; n=70; mean age 65 ± 4 y) who measured plasma 51 Cr‐ EDTA ‐Clearance ( mGFR ) had mGFR compared to eGFR obtained by the Cockcroft–Gault corrected by body surface area ( CG ‐ BSA ), the modification of diet in renal disease ( MDRD ‐4), the Berlin Initiative Study ( BIS ‐1), and the chronic kidney disease epidemiology collaboration ( CKD ‐ EPI ). Results were validated using a cohort of 43, of the 70 elderly recipients, who performed a second 51 Cr‐ EDTA ‐Clearance. Mean mGFR was 47 ± 16 mL/min/1.73 m 2 and statistically lower than eGFR by MDRD (52 ± 19, P =.001) and BIS ‐1 (51 ± 13, P =.007) but not different from the CG ‐ BSA (47 ± 15) and CKD ‐ EPI (49 ± 18). The CKD ‐ EPI and CG ‐ BSA presented the lowest bias but only CKD ‐ EPI also showed the highest 30% and 10% accuracy. The same findings were repeated in the validation set. For a cohort of elderly recipients ≥65 years (n=35, 68 ± 3y), the CKD ‐ EPI performed better with the lowest bias (0 ± 12 mL/min/1.73 m 2 ) and best 30% and 10% accuracy. The CKD ‐ EPI equation is a valuable tool to monitor GFR in the elderly RT x recipients.