Ripples on spikes show increased phase‐amplitude coupling in mesial temporal lobe epilepsy seizure‐onset zones

Abstract

Generation of low-frequency (80-150 Hz) pRipples in the SOZ involves coupling between epileptiform spike phase and ripple amplitude. The changes in excitability reflected as epileptiform spikes may also cause clusters of pathologically interconnected bursting neurons to grow and synchronize into aberrantly large neuronal assemblies.